文章基本信息

标题：Effect of Berberine on Bone Mineral Density in SAMP6 as a Senile Osteoporosis Model
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作者：Huiying Li ; Tatsuro Miyahara ; Yasuhiro Tezuka 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：2003
卷号：26
期号：1
页码：110-111
DOI：10.1248/bpb.26.110
出版社：The Pharmaceutical Society of Japan
摘要：The effects of berberine in senescence accelerated mice P6 (SAMP6) were investigated to learn whether the alkaloid affects bone mineral density (BMD). Oral administration of berberine (10 mg/kg/d) to male and female mice for 22 weeks resulted in an increase in BMD in both sexes. A decreased concentration of deoxypyridinoline (Dpd) in urine was only observed in female mice. There was no effect on body or tibia weight or on the concentration of procollagen type I carboxyterminal extension peptide (PICP) in serum.
关键词：berberine;senescence accelerated mice P6 (SAMP6);bone mineral density (BMD);deoxypyridinoline (Dpd);procollagen type I carboxyterminal extension peptide (PICP)