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标题：Total Coenzyme Q10 Concentrations in Asian Men Following Multiple Oral 50-mg Doses Administered as Coenzyme Q10 Sustained Release Tablets or Regular Tablets
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作者：Wan-Liang Lu ; Qiang Zhang ; How-Sung Lee 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：2003
卷号：26
期号：1
页码：52-55
DOI：10.1248/bpb.26.52
出版社：The Pharmaceutical Society of Japan
摘要：Coenzyme Q₁₀ (CoQ₁₀), a highly lipophilic compound present in the inner mitochondrial membrane, is essential for production of cellular energy in the form of ATP. CoQ₁₀ is used as a dietary supplement and for treatment of various cardiovascular disorders. Our goal was to compare the CoQ₁₀ levels in Asians following multiple oral doses administered as sustained release or regular tablets. Twenty healthy male volunteers (19—23 years old) were divided into two equal groups. Each subject in Group I received 50 mg oral doses of coenzyme Q₁₀ as sustained release tablets once a day for fifteen days, while subject in Group II received 50 mg doses of coenzyme Q₁₀ regular tablets. The CoQ₁₀ levels were measured by HPLC-UV (reverse phase ODS column, 10 μm, 250×4.6 mm; oven temperature 30 °C). Mobile phase was constituted by methanol–ethanol 9 : 1 v/v. Flow rate was 1.5 ml/min and UV detection was carried out at 275 nm. Coenzyme Q₉ was used as an internal standard. CoQ₁₀ baseline in the morning was 0.88±0.48 mg/l. Following 1 week 50 mg/d dosing of CoQ₁₀, plasma CoQ₁₀ concentrations increased to 1.85±1.03 mg/l for sustained release tablets and up to 1.37±0.74mg/l for regular tablets. The net increment proportion in AUC for sustained release and regular tablets were 148.26±176.56%, 102.57±130.00%, respectively. Both preparations significantly increased the systemic exposure when compared to endogenous baseline.
关键词：Coenzyme Q10;sustained release tablets;HPLC-UV;plasma concentration;Asian human healthy volunteer