文章基本信息

标题：Peroxisome Proliferative Drugs Do not Induce an Increase of Rat Mevalonate Pyrophosphate Decarboxylase
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作者：Akihiro Michihara ; Makoto Sawamura ; Yukio Yamori 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：2003
卷号：26
期号：1
页码：93-95
DOI：10.1248/bpb.26.93
出版社：The Pharmaceutical Society of Japan
摘要：To determine whether or not the expression of mevalonate pyrophosphate decarboxylase (MPD) depends on the proliferation of peroxisomes, we examined change in the protein level of MPD in the crude extract, the cytosol and the peroxisome-enriched fraction of the livers of rats administered peroxisome proliferative drugs. No increase of MPD was observed in any of these fractions. These data suggest that the expression of MPD is independent of the proliferation of peroxisomes and may be maintained via a specific regulatory mechanism different from that of the expression of peroxisome proliferator-activated receptor alpha.
关键词：mevalonate pyrophosphate decarboxylase;peroxisome;rat;liver