文章基本信息

标题：Antihypertensive Effect of Sesamin. IV. Inhibition of Vascular Superoxide Production by Sesamin
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作者：Daisuke Nakano ; Chie Itoh ; Masanori Takaoka 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：2002
卷号：25
期号：9
页码：1247-1249
DOI：10.1248/bpb.25.1247
出版社：The Pharmaceutical Society of Japan
摘要：We previously demonstrated the preventive effect of sesamin, a lignan from sesame oil, on the development of several experimental models of hypertension. In the present study, we explored the mechanisms underlying the antihypertensive effect of sesamin using the deoxycorticosterone acetate (DOCA)-salt rat hypertensive model. After a 5-week treatment period, aortic superoxide (O₂⁻) production was measured in the lucigenin chemiluminescence assay. Chemiluminescence signals significantly decreased in sesamin-containing diet-fed DOCA-salt hypertensive rats compared with those in the normal diet-fed DOCA-salt rats, although the signals in sham-operated control animals were not affected by the sesamin feeding. In addition, there was a positive correlation between systolic blood pressure and aortic O₂⁻ production. These findings suggest that sesamin feeding inhibits enhanced vascular O₂⁻ production in DOCA-salt hypertensive rats and that the antioxidative action of sesamin may contribute to its antihypertensive activity.
关键词：sesamin;deoxycorticosterone acetate (DOCA)-salt hypertension;superoxide