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标题：An Antiprogesterone, Onapristone, Enhances the Gene Expression of Promatrix Metalloproteinase 3/Prostromelysin-1 in the Uterine Cervix of Pregnant Rabbit
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作者：Keisuke Imada ; Takashi Sato ; Kazuyoshi Hashizume 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：2002
卷号：25
期号：9
页码：1223-1227
DOI：10.1248/bpb.25.1223
出版社：The Pharmaceutical Society of Japan
摘要：Using a progesterone receptor antagonist, onapristone/ZK 98.299, we examined the in-vivo effects of progesterone on the function of uterine cervix during pregnancy. Onapristone was intravenously administered to pregnant rabbits on day 20 post coitum . After 24 h, the antiprogesterone increased the wet weight of the uterine cervix and decreased the DNA concentration in the cervix. In-situ hybridization also indicated that antiprogesterone augmented the expression of matrix metalloproteinase (MMP)-3/stromelysin-1 mRNA in the uterine cervix. These changes are very similar to those observed and reported thus far in ripened and dilated uterine cervix. These results suggest that during pregnancy, progesterone closely participates in the maintenance of the function of uterine cervix by preventing the production of MMPs and thereby destruction of extracellular matrix, and thus add support to the theory that antiprogesterone has the potential to accelerate for the uterine cervical ripening and dilatation.
关键词：uterine cervical ripening;prostromelysin-1;promatrix metalloproteinase-3;antiprogesterone;onapristone/ZK 98.299