文章基本信息

标题：Frequency and Genetic Characterization of Multidrug-Resistant Mutants of Staphylococcus aureus after Selection with Individual Antiseptics and Fluoroquinolones
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作者：Norihisa Noguchi ; Maki Tamura ; Koji Narui 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：2002
卷号：25
期号：9
页码：1129-1132
DOI：10.1248/bpb.25.1129
出版社：The Pharmaceutical Society of Japan
摘要：The frequency of generation of multidrug-resistant mutants of Staphylococcus aureus was examined by selection with various antiseptics and fluoroquinolones and the mutated genes were characterized. Multidrug-resistant mutants with mutation of the region between the promoter and structural regions of the norA gene were generated more frequently during selective pressure with antiseptics than during selective pressure with FQs. We also obtained evidence for the existence of at least one other gene related to resistance to antiseptics and fluoroquinolones on the chromosome of S. aureus in addition to norA gene.
关键词：Staphylococcus aureus;multidrug-resistant mutant;fluoroquinolone;antiseptic;norA