文章基本信息

标题：Neuroprotective Effects of Constituents of the Oriental Crude Drugs, Rhodiola sacra, R. sachalinensis and Tokaku-joki-to, against Beta-amyloid Toxicity, Oxidative Stress and Apoptosis
本地全文：下载
作者：Inhee Mook-Jung ; Hee Kim ; Wenzhe Fan 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：2002
卷号：25
期号：8
页码：1101-1104
DOI：10.1248/bpb.25.1101
出版社：The Pharmaceutical Society of Japan
摘要：We tested the constituents of two Rhodiola plants, Rhodiola sacra S. H. F U and R. sachalinensis A. B OR , and an Oriental crude drug, Tokaku-joki-to, for their neuroprotective effects. Of the 58 compounds tested, six had considerable protective effects against beta-amyloid-induced death of B103 neuronal cells in vitro . These six compounds also showed protective effects against staurosporine-induced cell death, and two of the six compounds protected neurons from H₂O₂-induced cell death. These results suggest that some of the tested compounds protect neurons from beta-amyloid toxicity based on antiapoptotic and antioxidative activity.
关键词：beta-amyloid;apoptosis;oxidative stress;natural medicine;Alzheimer's disease;B103 cell