文章基本信息

标题：Isolation of a Novel Peptide Homing to Tumor-Derived Neovasculature That Suppresses Tumor Growth
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作者：Tomohiro Asai ; Hideto Fukatsu ; Koichi Kuromi 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：2002
卷号：25
期号：7
页码：904-906
DOI：10.1248/bpb.25.904
出版社：The Pharmaceutical Society of Japan
摘要：Novel peptides homing to angiogenic vessels were recently isolated from a phage-displayed random pentadecapeptide library, and peptides having WRP sequence showed tumor growth suppression. In this study, we observed that another novel sequence, PVVLFPLH, suppressed tumor growth in vivo . Through the study of tumor growth suppression by the 5-mer peptides derived from this sequence, we determined the epitope sequence to be LFPLH. LFPLH, but not the shuffled peptide FHLLP, suppressed the migration of vascular endothelial growth factor-stimulated human umbilical vein endothelial cells. Interestingly, growth suppression of LFPLH against the cells as well as tumor cells was not observed in vitro . Therefore LFPLH may function to induce tumor dormancy through inhibition of angiogenesis.
关键词：phage-displayed peptide library;angiogenesis;tumor dormancy;drug delivery system