文章基本信息

标题：Transdermal Delivery of Indomethacin by Iontophoresis
本地全文：下载
作者：Makoto Kanebako ; Toshio Inagi ; Kozo Takayama 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：2002
卷号：25
期号：6
页码：779-782
DOI：10.1248/bpb.25.779
出版社：The Pharmaceutical Society of Japan
摘要：The objective of this study was to construct a modified equation for the delivery of a drug by iontophoresis. Indomethacin was selected as a model since it has been widely used as a non-steroidal anti-inflammatory drug (NSAID) for external pharmaceutical preparations. The experiments were performed under a constant current in vivo using rat abdominal skin, and the plasma concentration was monitored by HPLC. Pharmacokinetic parameters were obtained from the plasma concentration profiles after intravenous injection. A theoretical value of the transdermal delivery of drug by iontophoresis was calculated from the plasma concentration and pharmacokinetic parameters. The experimental value was evidently higher than the theoretical one, suggesting the enhancement of passive diffusion with an increase of applied current. The modified equation was proposed for the delivery of a drug by iontophoresis incorporating enhanced passive diffusion.
关键词：transdermal delivery;iontophoresis;plasma concentration;pharmacokinetic parameter;passive diffusion