文章基本信息

标题：Nobiletin as a Tyrosinase Inhibitor from the Peel of Citrus Fruit
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作者：Kenroh Sasaki ; Fumihiko Yoshizaki
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：2002
卷号：25
期号：6
页码：806-808
DOI：10.1248/bpb.25.806
出版社：The Pharmaceutical Society of Japan
摘要：A tyrosinase inhibitor was isolated from the peel of Citrus fruit by activity-guided fractionation, and identified as 3′,4′,5,6,7,8-hexamethoxyflavone (nobiletin) by comparison with reported spectral data. Nobiletin (IC₅₀ of; 46.2 μ M ) exhibited more potency than Kojic acid (IC₅₀; 77.4 μ M ) used as a positive control, and it was found to be potentially an effective inhibitor of the production of melanin.
关键词：nobiletin;Citrus peel;mushroom tyrosinase