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标题：In Vitro Antifungal Activity of Naphthoquinone Derivatives
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作者：Kenroh Sasaki ; Hidetomo Abe ; Fumihiko Yoshizaki 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：2002
卷号：25
期号：5
页码：669-670
DOI：10.1248/bpb.25.669
出版社：The Pharmaceutical Society of Japan
摘要：In vitro antifungal activities of naphtoquinone-derivatives, which are constituents of Shikon, roots of Lithospermum erythrorhizon, were investigated against several fungal pathogens. When the biological activity of these compounds was tested against fungi, a wide range of sensitivity was recorded. Shikonin was found to have a stronger than fluconazole against yeast-like fungi: four-fold against Candida krusei (minimal inhibitory concentration (MIC); 4 μg/ml) and two-fold (MIC; 4 μg/ml) against Saccharomyces cerevisiae , though it showed the same potency as fluconazole against C. glabrata . Deoxyshikonin also exhibited four-fold stronger activity against C. krusei (MIC; 4 μg/ml) and three-fold (MIC; 2 μg/ml) stronger against S. cerevisiae . Acetylshikonin and β-hydroxyisovaleryl shikonin showed lower activities against all fungal pathogens except for C. krusei compared with the standard. Against the filamentous fungus, Trichosporon cutaneum , all naphthoquinones were found to have a range of activity with lower potency than standard. This result provides a rational basis for the clinical use of shikon and shows the possibility of its use in medicinal treatment as an anti-inflammatory agent with antifungal activity.
关键词：antifungal activity;shikonin;deoxyshikonin;acetylshikonin;β-hydroxyisovaleryl shikonin