文章基本信息

标题：Cyclooxygenase-2 Inhibitory 1,4-Naphthoquinones from Impatiens balsamina L.
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作者：Hisae Oku ; Kyoko Ishiguro
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：2002
卷号：25
期号：5
页码：658-660
DOI：10.1248/bpb.25.658
出版社：The Pharmaceutical Society of Japan
摘要：Significant selective cyclooxygenase-2 (COX-2) inhibitory activities were observed for two new 1,4-naphthoquinone sodium salts, sodium 3-hydroxide-2{[sodium 3-hydroxide-1,4-dioxo(2-naphthyl)]ethyl}naphthalene-1,4-dione (impatienolate) (1) and sodium 2-hydroxide-3-(2-hydroxyethyl)naphthalene-1,4-dione (balsaminolate) (2), which were isolated from the corolla of Impatiens balsamina L. (Balsaminaceae). Their structures were elucidated by spectral techniques. Our results offer evidence supporting the use of I. balsamina L. to treat articular rheumatism, pain, and swelling.
关键词：Impatiens balsamina L.;1,4-naphthoquinone;impatienolate;balsaminolate;cyclooxygenase (COX) inhibitor;anti-inflammatory agent