文章基本信息

标题：Preventive Effects of Impatiens balsamina on the Hen Egg-White Lysozyme (HEL)-Induced Decrease in Blood Flow
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作者：Kyoko Ishiguro ; Yukiko Ohira ; Hisae Oku 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：2002
卷号：25
期号：4
页码：505-508
DOI：10.1248/bpb.25.505
出版社：The Pharmaceutical Society of Japan
摘要：Monitoring the blood flow of unanesthesized mice was found to be a reliable and effective method for studying their anaphylactic responses, in addition to the known method of monitoring blood pressure. Hen egg-white lysozyme (HEL)-specific anaphylaxis in mice was estimated by monitoring the decrease in blood flow with a Doppler blood flow meter. This method is convenient for searching for both anaphylaxis and anti-anaphylactic substances from natural products. Using this system, we estimated the anti-anaphylactic effects of the 35% ethanol extract (IB) of petals of Impatiens balsamina L., as well as those of anti-allergic agents currently used. Kaempferol 3-rutinoside and lawsone from IB significantly inhibited the decrease of blood flow. We also found that platelet-activating factor (PAF) and serotonin participate in decreasing the blood flow, but histamine does not.
关键词：anaphylaxis;blood flow monitoring;murine anaphylaxis;Impatiens balsamina L.;kaempferol 3-rutinoside;lawsone