文章基本信息

标题：Effects of Kangen-karyu on Coagulation System and Platelet Aggregation in Mice
本地全文：下载
作者：Toshiaki Makino ; Hannosuke Wakushima ; Takuya Okamoto 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：2002
卷号：25
期号：4
页码：523-525
DOI：10.1248/bpb.25.523
出版社：The Pharmaceutical Society of Japan
摘要：Kangen-karyu (KGK) is a herbal formula created under the theory of traditional Chinese herbal medicine to invigorate the blood and dispel blood stasis . It contains 6 herbs: peony root, cnidium rhizome, safflower, cyperus rhizome, saussurea root (JP XIV), and Salvia miltiorrhiza root. The present study has been conducted to evaluate the in vivo anti-thrombotic activity of KGK using normal mice. Three consecutive days of oral administration of KGK to mice significantly extended tail-bleeding time and suppressed ex vivo platelet aggregation, while it did not extend the prothrombin time of plasma. It was revealed that the anti-thrombotic effects of KGK did not depend on the downregulation of the coagulation system, but depended in part on the inhibition of platelet aggregation. These results explain one of the pharmacological activities of KGK to invigorate the blood and dispel blood stasis .
关键词：Salvia miltiorrhiza;anti-thrombosis;anti-coagulant;anti-platelet;Guan-xin No. 2