文章基本信息

标题：Recent Progress in α1-Adrenoceptor Pharmacology
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作者：Taka-aki Koshimizu ; Junji Yamauchi ; Akira Hirasawa 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：2002
卷号：25
期号：4
页码：401-408
DOI：10.1248/bpb.25.401
出版社：The Pharmaceutical Society of Japan
摘要：The adrenoceptors (ARs) play a key role in the modulation of sympathetic nervous system activity and are a site of action for many clinically important therapeutic agents. The α₁-adrenoceptor subtypes (α_1A-, α_1B-, and α_1D-AR) play a prominent role in regulating vascular tone and hypertrophic growth of smooth muscle and cardiac cells. Their functional characteristics with respect to ligand binding and second messenger utilization have been well described. Here, we review recent progress on subtype-specific subcellular localization, participation in signaling cascades, and the pivotal function of α₁-ARs, as delineated through studies on genetically engineered animals. Together, these findings will provide new insights into the physiological and pathophysiological roles of the α₁-ARs.
关键词：α1-adrenoceptor;cellular signaling;cellular localization;transgenic mouse;knockout mouse;pharmacogenomics