文章基本信息

标题：Latent Activity of Curcumin against Leishmaniasis in Vitro
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作者：Danish Saleheen ; Syed Atif Ali ; Khalid Ashfaq 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：2002
卷号：25
期号：3
页码：386-389
DOI：10.1248/bpb.25.386
出版社：The Pharmaceutical Society of Japan
摘要：In this study the anti-proliferative effect of curcumin (curcuma longa) that is the active ingredient of ground dried rhizome has been studied against three local and three reference leishmanial strains, Leishmania major , Leishmania tropica and Leishmania infantum (Pakistani isolate). Curcumin has shown an average IC₅₀ of 5.3 μ M against promastigotes of various leishmanial strains which is much lower as compared with pentamidine that is one of the basic treatments against leishmaniasis. The main draw back attributed to these assays performed on promastigotes is the heterogeneity of results compared with those obtained with intracellular amastigotes or with in vivo effect. We also tested activity of curcumin against axenic amastigote like cells (AALC) of L. major strain (MHOM/PK/88/DESTO). Curcumin proves to be far more potent then pentamidine against AALC which further strengthens the fact about its leishmaniacidal activity.
关键词：curcumin;leishmania;leishmanial promastigotes;axenic amastigote like cell