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标题：The Study on a PVC Membrane Electrode for Gemfibrozil
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作者：Fen Xu ; Li-Xian Sun ; Naoki Matsuda 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：2002
卷号：25
期号：2
页码：165-167
DOI：10.1248/bpb.25.165
出版社：The Pharmaceutical Society of Japan
摘要：In this paper, a poly(vinyl chloride) (PVC) membrane electrode is prepared for gemfibrozil, 2, 2-dimethyl-5-(2,5-xylyloxy) valeric acid, based on its ion pair complexes with hexadecyltrioctyl ammonium iodide (HTOA). The membrane composition of the electrode was optimized by using the sequential level elimination method for orthogonal experimental design. The electrode has a Nernstian response range from 2.5×l0⁻⁵ to 0.1 mol/l with an average slope of 55.3 mV/decade. The limit of detection is 7.l×l0⁻⁶ mol/l. The electrode responses were not affected by pH in the range 10.0—12.3. A Na₂B₄O₇–Na₂CO₃ buffer of pH=11.0 was selected as the background electrolyte solution for potentiometric measurements. The electrode was used for determining gemfibrozil in pharmaceutical preparations with satisfactory results.
关键词：gemfibrozil;ion selective electrode;orthogonal experimental design;quantitative determination