文章基本信息

标题：Cloning and Characterization of a Novel Chromosomal Drug Efflux Gene in Staphylococcus aureus
本地全文：下载
作者：Koji Narui ; Norihisa Noguchi ; Kazunori Wakasugi 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：2002
卷号：25
期号：12
页码：1533-1536
DOI：10.1248/bpb.25.1533
出版社：The Pharmaceutical Society of Japan
摘要：A novel drug efflux gene (named sepA , staphylococcal efflux pump gene) is cloned from antiseptic-resistant mutants of Staphylococcus aureus into Escherichia coli. The sepA gene conferred the reduction of susceptibility to acriflavine and the acceleration of ethidium bromide efflux from the E. coli cells. The sepA (474 bp) encoded the protein that has four predicted transmembrane segments. These results indicate that sepA gene is a multidrug-resistant gene and encodes a drug efflux protein.
关键词：Staphylococcus aureus;antiseptic resistance;efflux protein;transmembrane