文章基本信息

标题：Identification of Licocoumarone as an Apoptosis-Inducing Component in Licorice
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作者：Makoto Watanabe ; Sumio Hayakawa ; Mamoru Isemura 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：2002
卷号：25
期号：10
页码：1388-1390
DOI：10.1248/bpb.25.1388
出版社：The Pharmaceutical Society of Japan
摘要：The 70% methanol soluble fraction from a licorice acetone extract was found to inhibit cell proliferation in human monoblastic leukemia U937 cells by inducing apoptosis. Separation by the methods including preparative HPLC provided us with an active compound, which was identified as licocoumarone. Several lines of evidence indicated that licocoumarone induced apoptosis in U937 cells. Thus, licocoumarone is suggested to be potentially useful as a natural anti-cancer agent.
关键词：licorice;apoptosis;licocoumarone;Glycyrrhiza glabra;U937 cell