文章基本信息

标题：Antiproliferative Sesquiterpene Lactones from the Roots of Inula helenium
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作者：Tenji Konishi ; Yasuo Shimada ; Tsuneatsu Nagao 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：2002
卷号：25
期号：10
页码：1370-1372
DOI：10.1248/bpb.25.1370
出版社：The Pharmaceutical Society of Japan
摘要：The MeOH extract of the roots of Inula helenium showed a high inhibitory activity for cell growth against MK-1, HeLa and B16F10 cell lines. Significant activity was found in the hexane-soluble fraction. From the hexane-soluble fraction, seven sesquiterpenes, namely, one germacrane (4β,5α-epoxy-1(10),11(13)-germacradiene-8,12-olide), one elemane (igalane), and five eudesmanes (alantolactone, isoalantolactone, 11α,13-dihydro-alantolactone, 11α,13-dihydro-isoalantolactone, 5-epoxyalantolactone) were isolated. In vitro antiproliferative activities of the isolates against MK-1, HeLa and B16F10 cells are reported.
关键词：Inula helenium;Compositae;antiproliferative activity;sesquiterpene lactone;igalan;alantolactone