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标题：Effects of Peripheral Administration of 5-Hydroxytryptamine (5-HT) on 2-Deoxy-D-glucose-Induced Hyperphagia in Rats
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作者：Yumi Sugimoto ; Tomoko Yoshikawa ; Jun Yamada 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：2002
卷号：25
期号：10
页码：1364-1366
DOI：10.1248/bpb.25.1364
出版社：The Pharmaceutical Society of Japan
摘要：Effects of peripheral administration of 5-HT (5-hydroxytryptamine, serotonin) on hyperphagia induced by 2-deoxy- D -glucose(2-DG) were studied in rats. It was found that 5-HT i.p. reduced 2-DG-elicited feeding in rats dose-dependently. The 5-HT-induced hypophagia was antagonized by the 5-HT_2A receptor antagonist, ketanserin. It is known that 2-DG induces glucoprivation, resulting in hyperphagia and hyperglycemia. However, 5-HT did not affect hyperglycemia induced by 2-DG. These results suggest that peripheral injection of 5-HT reduces 2-DG-induced hyperphagia mediated by the peripheral 5-HT_2A receptor and that its effects are not due to enhancement of hyperglycemia.
关键词：5-HT (5-hydroxytryptamine, serotonin);food intake;2-deoxy- D -glucose;peripheral 5-HT2A receptor;glucoprivation