文章基本信息

标题：Molecular Genetics and Subjective Well-Being
本地全文：下载
作者：Meike Bartels ; Daniel Benjamin ; David Cesarini 等
期刊名称：CEP Discussion Paper
出版年度：2013
卷号：2013
语种：English
出版社：Centre for Economic Performance
摘要：Subjective well-being (SWB) is a major topic of research across the social sciences. Twin and family studies have found that genetic factors may account for as much as 30-40% of the variance in SWB. Here, we study genetic contributions to SWB in a pooled sample of ~11,500 unrelated, comprehensively-genotyped Swedish and Dutch individuals. We apply a recently-developed method to estimate "common narrow heritability": the fraction of variance in SWB that can be explained by the cumulative additive effects of genetic polymorphisms that are common in the population. Our estimates are 5-10% for single-question survey measures of SWB, and 12-18% after correction for measurement error in the SWB measures. Our results suggest guarded optimism about the prospects of using genetic data in SWB research because, while the common narrow heritability is not large, the polymorphisms that contribute to it could feasibly be discovered with a sufficiently large sample of individuals.
关键词：subjective well-being;heritability;genetics;GREML