文章基本信息

标题：Dehydrotrametenolic Acid Induces Preadipocyte Differentiation and Sensitizes Animal Models of Noninsulin-Dependent Diabetes Mellitus to Insulin
本地全文：下载
作者：Mayumi Sato ; Takaaki Tai ; Yoshiki Nunoura 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：2002
卷号：25
期号：1
页码：81-86
DOI：10.1248/bpb.25.81
出版社：The Pharmaceutical Society of Japan
摘要：We recently discovered that the triterpene acid compound dehydrotrametenolic acid promotes adipocyte differentiation in vitro and acts as an insulin sensitizer in vivo . This natural product has been isolated from dried sclerotia of Poria cocos Wolf (Polyporaceae), a well-known traditional Chinese medicinal plant. We examined the effects of dehydrotrametenolic acid on plasma glucose concentration in obese hyperglycemic db / db mice. Dehydrotrametenolic acid can reduce hyperglycemia in mouse models of noninsulin-dependent diabetes mellitus (NIDDM) and act as an insulin sensitizer as indicated by the results of the glucose tolerance test. These terpenoids and thiazolidine type of antidiabetic agents such as Ciglitazone, although structurally unrelated, share many biological activities: both induce adipose conversion, activate peroxisome proliferator-activated receptor γ (PPAR γ) in vitro , and reduce hyperglycemia in animal models of NIDDM. Dehydrotrametenolic acid is a promising candidate for a new type of insulin-sensitizing drug. This finding is very important for the development of insulin sensitizers that are not of the thiazolidine type.
关键词：adipocyte differentiation;noninsulin-dependent diabetes mellitus;triterpene;dehydrotrametenolic acid;pachymic acid;peroxisome proliferator-activated receptor γ (PPAR γ)