文章基本信息

标题：(+)-α-Viniferin, a Stilbene Trimer from Caragana chamlague, Inhibits Acetylcholinesterase
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作者：Sang Hyun Sung ; So Young Kang ; Ki Yong Lee 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：2002
卷号：25
期号：1
页码：125-127
DOI：10.1248/bpb.25.125
出版社：The Pharmaceutical Society of Japan
摘要：In the course of screening natural products for anti-acetylcholinesterase (AChE) activity, we found that a total methanolic extract of the underground parts of Caragana chamlague (Leguminosae) had significant inhibition towards AChE. Bioactivity-guided fractionation of the total methanolic extract resulted in the isolation and identification of two active stilbene oligomers, (+)-α-viniferin (1) and kobophenol A (2). Both 1 and 2 inhibited AChE activity in a dose-dependent manner, and the IC₅₀ values of 1 and 2 were 2.0 and 115.8 µM, respectively. The AChE inhibitory activity of 1 was specific, reversible and noncompetitive.
关键词：Caragana chamlague;Leguminosae;AChE inhibitors;(+)-α-viniferin;kobophenol A