文章基本信息

标题：Inhibitory Activities of (−)-Epigallocatechin-3-O-gallate against Topoisomerases I and II
本地全文：下载
作者：Keitarou SUZUKI ; Shoji YAHARA ; Fumio HASHIMOTO 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：2001
卷号：24
期号：9
页码：1088-1090
DOI：10.1248/bpb.24.1088
出版社：The Pharmaceutical Society of Japan
摘要：The substitution of gallic acid at the 3 position of (−)-epigallocatechin-3-O-gallate (EGCG) increased the inhibition against topoisomerase I from calf thymus gland and topoisomerase II from human placenta, and the substitution of a hydroxyl group at the 3' position increased the inhibition against the topoisomerase I. These results suggested that the 3 and 3' positions of the EGCG molecule play important roles in the process of inhibition of topoisomerases I and II. EGCG showed strong inhibition against topoisomerases I from wheat germ, calf thymus gland and Vero cells, and showed weak or no inhibition against topoisomerases I from carcinoma cells such as A549, HeLa and COLO 201 cells. EGCG differentially inhibited the topoisomerases I from different sources.
关键词：epigallocatechin-3-O-gallate;topoisomerase inhibition;EGCG;catechin