文章基本信息

标题：Effects of Mosapride Citrate on Human Plasma Levels of Motilin, Gastrin, Somatostatin, and Secretin
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作者：Hiroki ITOH ; Toshiaki NAGANO ; Masaharu TAKEYAMA 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：2001
卷号：24
期号：9
页码：1072-1075
DOI：10.1248/bpb.24.1072
出版社：The Pharmaceutical Society of Japan
摘要：The effect of mosapride citrate (mosapride) on plasma levels of gastrointestinal peptides (motilin, gastrin, somatostatin, and secretin) was studied in five healthy volunteers. After a single oral administration of mosapride (15 mg), the plasma mosapride level (85.0±13.7 ng/ml) was highest in the 60-min sample after the administration and then the plasma level fell. Peak plasma motilin levels (18.6±1.7 pg/ml) were achieved 60 min after administration of mosapride (p<0.01 vs. placebo), and returned to baseline levels within a further 120 min. Plasma gastrin levels (42.4±3.6 pg/ml) increased 60 min after administration of mosapride (p<0.01 vs. placebo). Plasma somatostatin and secretin levels did not change significantly. These results suggest that the pharmacological effects of mosapride on gastrointestinal functions are closely related to changes in motilin-immunoreactive substance levels in human plasma.
关键词：mosapride;motilin;gastrin;somatostatin;secretin