文章基本信息

标题：Calcium Signals in Rat Basophilic Leukemia (RBL-2H3) Cells Primed with the Neuropeptide Substance P
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作者：Yoko FURUKAWA ; Tadahide FURUNO ; Reiko TESHIMA 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：2001
卷号：24
期号：9
页码：1060-1063
DOI：10.1248/bpb.24.1060
出版社：The Pharmaceutical Society of Japan
摘要：Communication between nerves and mast cells is a prototypic demonstration of neuroimmune interaction. We have recently shown that direct nerve-mast cell cross-talk can occur in the absence of an intermediary transducing cell and that the neuropeptide substance P is an important mediator of this communication. Here we study the calcium signals in rat basophilic leukemia cells (RBL-2H3; mucosal-type mast cells) primed with substance P. RBL cells responded only slightly to stimulation with compound 48/80, however they responded to the stimulation when the cells had been primed with substance P (0.5 μM) for one week. The present results provide a foundation to study the neuroimmune cross-talk in a co-culture system.
关键词：RBL-2H3 cell;calcium signal;substance P;compound 48/80;neuroimmune interaction;G protein