文章基本信息

标题：Identification of 16α,19-Dihydroxyandrostenedione in the Serum of Pregnant Women by Gas Chromatography-Mass Spectrometry
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作者：Mitsuteru NUMAZAWA ; Satoshi SATOH ; Masao NAGAOKA 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：2001
卷号：24
期号：8
页码：947-949
DOI：10.1248/bpb.24.947
出版社：The Pharmaceutical Society of Japan
摘要：16α,19-Dihydroxyandrostenedione [16α,19-(OH)₂ AD], a potential precursor of estriol, was identified in the serum of pregnant women by gas chromatography-mass spectrometry (GC-MS). Preliminary study indicated that the average serum concentration of 16α,19-(OH)₂ AD in 10 normal pregnant women was 154.2±20 pg/ml. In contrast, the serum concentration of 16α,19-dihydroxydehydroepiandrosterone was less than the detection limit (30 pg/ml) of the GC-MS method.
关键词：16α,19-dihydroxy androgen;serum concentration;pregnant woman;estriol formation;feto-placental unit