文章基本信息

标题：Thymidine Phosphorylase Inhibitors with a Homophthalimide Skeleton
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作者：Tetsuya KITA ; Hiroyasu TAKAHASHI ; Yuichi HASHIMOTO 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：2001
卷号：24
期号：7
页码：860-862
DOI：10.1248/bpb.24.860
出版社：The Pharmaceutical Society of Japan
摘要：Several N-phenylhomophthalimide derivatives were prepared and their inhibitory activity on thymidine phosphorylase/platelet-derived endothelial cell growth factor (TP/PD-ECGF) was assessed. Among them, 2-(2,6-diethylphenyl)-7-nitro-1,2,3,4-tetrahydroisoquinoline-1,3-dione (9) was found to be a more potent inhibitor than the classical inhibitor, 5-nitrouracil (1). Lineweaver-Burk plot analysis indicated that 9 shows mixed-type competitive inhibition TP/PD-ECGF, while 1 is a competitive inhibitor.
关键词：homophthalimide;thymidine phosphorylase;inhibitor;platelet-derived endothelial cell growth factor