文章基本信息

标题：Inhibitory Effects of Anti-Inflammatory Drugs on Interleukin-6 Bioactivity
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作者：Bo-Seong KANG ; Eun-Yong CHUNG ; Yeo-Pyo YUN 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：2001
卷号：24
期号：6
页码：701-703
DOI：10.1248/bpb.24.701
出版社：The Pharmaceutical Society of Japan
摘要：Interleukin-6 (IL-6) is known as a proinflammatory cytokine involved in immune response, inflammation, and hematopoiesis. Inhibitory effects of anti-inflammatory drugs on IL-6 bioactivity using IL-6-dependent hybridoma have been evaluated. Three out of 16 nonsteroidal anti-inflammatory drugs (NSAIDs) showed IC₅₀ values of less than 100 μM, which were in the order of oxyphenylbutazone hydrate (IC₅₀=7.5 μM)>meclofenamic acid sodium salt (31.9 μM)>sulindac (74.9 μM). Steroidal anti-inflammatory drugs (SAIDs) exhibited significant inhibitory effects at 100 μM on the IL-6 bioactivity, and their inhibitory potencies were in the order of budesonide (IC₅₀=2.2 μM)>hydrocortisone 21-hemisuccinate (6.7 μM), prednisolone (7.5 μM), betamethasone (10.9 μM)>dexamethasone (18.9 μM) and triamcinolone acetonide (24.1 μM). The results would provide an additional mechanism by which anti-inflammatory drugs display their anti-inflammatory and immunosuppressive effects at higher concentrations.
关键词：anti-inflammatory drugs;IL-6 inhibitor;oxyphenylbutazone hydrate;budesonide