文章基本信息

标题：Prevention of the Neurotoxicity of the Amyloid β Protein by Genipin
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作者：Matsumi YAMAZAKI ; Naoki SAKURA ; Kenzo CHIBA 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：2001
卷号：24
期号：12
页码：1454-1455
DOI：10.1248/bpb.24.1454
出版社：The Pharmaceutical Society of Japan
摘要：Genipin, which was shown in our previous investigation to have prominent neuritogenic activity in paraneurons such as PC12h cells, was studied to determine whether it could prevent the toxicity of Alzheimer’s amyloid β protein (Aβ) in cultured hippocampal neurons. Increased release of lactate dehydrogenase from hippocampal neurons after 2 d of Aβ25-35 administration was prevented dose dependently by the addition of genipin 20—40 μM. Morphological observations and trypan blue staining of cells confirmed the protection of hippocampal neurons from Aβ toxicity by genipin. Geniposide had less effect in preventing Aβ toxicity.
关键词：amyloid β protein;hippocampal neuron;genipin;neurotoxicity;neuroprotection