文章基本信息

标题：The 5-HT2C/2B Receptor Agonist m-Chlorophenylpiperazine (mCPP) Inhibits 2-Deoxy-D-glucose (2-DG)-Induced Hyperphagia in Rats
本地全文：下载
作者：Yumi SUGIMOTO ; Tomoko YOSHIKAWA ; Toshiko NOMA 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：2001
卷号：24
期号：12
页码：1431-1433
DOI：10.1248/bpb.24.1431
出版社：The Pharmaceutical Society of Japan
摘要：Effects of the 5-HT_2C/2B receptor agonist m-chlorophenylpiperazine (mCPP) on hyperphagia elicited by 2-deoxy-D-glucose (2-DG) were investigated in rats. mCPP apparently reduced 2-DG-induced hyperphagia. Suppressive effects of mCPP on hyperphagia induced by 2-DG were inhibited by the 5-HT_2A/2B/2C receptor antagonist, ritanserin, although the 5-HT_2A receptor antagonist ketanserin was without effect. Thus, inhibitory effects of mCPP on 2-DG-induced hyperphagia are mediated by the 5-HT_2C/2B receptor. Our results demonstrate that mCPP can inhibit the bulimia model, 2-DG-induced hyperphagia.
关键词：5-HT2C/2B receptor;m-chlorophenylpiperazine (mCPP);2-deoxy-D-glucose (2-DG);hyperphagia