文章基本信息

标题：Trifluoromethyl Ketone-Based Inhibitors of Apoptosis in Cerebellar Granule Neurons
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作者：Masami KAWASE ; Katsuyoshi SUNAGA ; Satoru TANI 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：2001
卷号：24
期号：11
页码：1335-1337
DOI：10.1248/bpb.24.1335
出版社：The Pharmaceutical Society of Japan
摘要：A variety of aromatic trifluoromethyl ketone derivatives has been studied as inhibitors of apoptosis in cerebellar granule neurons (CGNs). Among them, α-trifluoromethyl diketone (2) and benzyl trifluoromethyl ketone (11) were found to be apoptosis inhibitors which can prevent a neurodegenerative disease. Compounds 2 and 11 showed neuroprotection effect on low K⁺-induced apoptosis in CGNs. Furthermore, these compounds effectively suppressed DNA fragmentation accompanied with apoptosis. The neuroprotection mode of 2 and 11 was not related to inhibition of caspase-3.
关键词：trifluoromethyl ketone;apoptosis;cerebellar granule neuron;neuroprotection;DNA fragmentation