文章基本信息

标题：Initial Intraorgan Formation of Mercapturic Acid
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作者：Kazumi SANO ; Yoji IKEGAMI ; Takashi UESUGI 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：2001
卷号：24
期号：11
页码：1324-1328
DOI：10.1248/bpb.24.1324
出版社：The Pharmaceutical Society of Japan
摘要：The disposition of S-benzyl-glutathione (BSG) in male Wistar rats was evaluated by the HPLC method to examine whether the kidney and liver contributed independently to the biosynthesis of S-benzyl-N-acetylcysteine (BNAc), a mercapturic acid (Chart 1). After intravenous injection, BSG was rapidly transported in both the kidney and the liver at a ratio of about 7:3. Simultaneously, a large amount of BNAc was found in both the kidney and the liver. In the kidney, S-benzyl-cysteine (BCys) reached a maximum concentration (C_max) at 2 min after BSG injection, whereas BNAc reached C_max within 3 to 5 min. The generation of BNAc was also observed in the liver. While renal BNAc reached C_max within 3 to 5 min, hepatic BNAc reached C_max around 5 min after BSG injection. Moreover, the elimination half-life of the BNAc after intravenous injection of the BSG was equivalent to that observed after intravenous injection of the BNAc itself. These results demonstrate that the kidney contributes to the initial intraorgan generation of BNAc and that this mercapturic acid is also synthesized in the liver and preferentially excreted into urine.
关键词：S-benzyl glutathione;intraorgan;mercapturic acid;retrograde;renal excretion;hepatobiliary