文章基本信息

标题：Effects of the 5-HT2 Receptor Antagonist, Ritanserin on Hyperthermia and Depletion of 5-HT in Frontal Cortex Induced by a 5-HT Releasing Drug, p-Chloroamphetamine (PCA) in Mice
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作者：Jun YAMADA ; Yumi SUGIMOTO ; Minako OHKURA 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：2001
卷号：24
期号：10
页码：1195-1197
DOI：10.1248/bpb.24.1195
出版社：The Pharmaceutical Society of Japan
摘要：Effects of the 5-HT₂ receptor antagonist, ritanserin on hyperthermia and depletion of 5-HT induced by the 5-HT-releasing drug, p-chloroamphetamine (PCA) were investigated. Ritanserin significantly suppressed PCA-induced hyperthermia in mice. PCA elicited decreases in 5-HT levels in the mouse frontal cortex. 5-HT reduction elicited by PCA was also attenuated by pretreatment with ritanserin. Since hyperthermia facilitates neurotoxicity induced by amphetamine analogue, ritanserin may inhibit PCA-induced 5-HT neurotoxicity by inhibiting hyperthermia.
关键词：p-chloroamphetamine;hyperthermia;5-HT2 receptor;neurotoxicity