文章基本信息

标题：Circumvention of Acquired Resistance to Doxorubicin in K562 Human Leukemia Cells by Oxatomide
本地全文：下载
作者：Masaaki ISHIKAWA ; Ryousuke FUJITA ; Shinobu FURUSAWA 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：2001
卷号：24
期号：10
页码：1185-1187
DOI：10.1248/bpb.24.1185
出版社：The Pharmaceutical Society of Japan
摘要：We studied the effect of oxatomide, an antiallergic drug, on the resistance of K562 cells to doxorubicin. Oxatomide synergistically potentiated the cytotoxicity of doxorubicin in doxorubicin-resistant K562 cells (K562/DXR) at a concentration of 1—10 μM, but had hardly any synergistic effect on the parental cell line (K562) at the same concentration. Oxatomide inhibit P-glycoprotein pump-efflux activity and the binding of [³H]-azidopine to the cell-surface protein P-glycoprotein, in a dose-related manner. These results indicate that oxatomide reverses the multidrug-resistance phenotype through direct interaction with P-glycoprotein.
关键词：K562 cell;oxatomide;verapamil;doxorubicin;multidrug resistance