文章基本信息

标题：Na+ and K+ Dependence of L-Glutamate-Induced Suppression of Astrocyte Stellation in Culture
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作者：Kazuho ABE ; Hiroshi SAITO
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：2001
卷号：24
期号：1
页码：50-53
DOI：10.1248/bpb.24.50
出版社：The Pharmaceutical Society of Japan
摘要：We have recently found that L-glutamate suppresses astrocyte stellation induced by various stimuli, and that this effect of L-glutamate is mimicked by transportable glutamate uptake inhibitors. To test the possible role of the glutamate transporter in the regulation of astrocyte morphology, we investigated the Na⁺ and K⁺ dependence of this effect of L-glutamate. In astrocyte cultures obtained from the cerebral cortex of neonatal rats, the L-glutamate-induced suppression of astrocyte stellation was significantly attenuated in a low-Na⁺/high-K⁺ medium and by the Na⁺-K⁺ pump inhibitor ouabain. These results support that astrocyte morphology is affected by the activity of the Na⁺-dependent glutamate transporter.
关键词：astrocyte;morphology;L-glutamate;glutamate transporter;ouabain;culture