文章基本信息

标题：Carcinogenic effects of N-nitroso compounds in the environment
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作者：Divya Jain ; Priya Chaudhary ; Nidhi Varshney 等
期刊名称：Environment Conservation Journal
印刷版ISSN：0972-3099
电子版ISSN：2278-5124
出版年度：2020
卷号：21
期号：3
DOI：10.36953/ECJ.2020.21304
语种：English
出版社：Action for Sustainable Efficacious Development and Awareness
摘要：N-nitroso compounds (NOC) are produced by the acid catalyzed reaction of nitrite with certain nitrogen compounds. The gastrointestinal tract (GI) is the main site for the formation of reactive nitrogen species (RNS). Bacteria present on the GI tract surface reduced the dietary nitrate or nitrite into Nitric oxide NO and other related compounds. The clinical sign of NOC carcinogenicity varies according to species, dose, and route of administration. Humans are exposed to preformed N-nitroso compounds and endogenous NOC via the environmental food chain. Several NOC are potential human carcinogens, including DENA and NDMA, but evidence from population studies is inconsistent.