文章基本信息

标题：Neural functional connectivity during rumination in individuals with adverse childhood experiences
本地全文：下载
作者：Andrzej Sokołowski ; Joachim Kowalski ; Małgorzata Dragan 等
期刊名称：European Journal of Psychotraumatology
印刷版ISSN：2000-8198
电子版ISSN：2000-8066
出版年度：2022
卷号：13
期号：1
页码：1-12
DOI：10.1080/20008198.2022.2057700
语种：English
出版社：Taylor & Francis Group
摘要：Childhood adversity has been associated with greater risk of developing psychopathology, altered processing of emotional stimuli, and changes in neural functioning. Although the neural correlates of rumination have been previously described, little is known about how adverse childhood experiences are related to brain functioning during rumination. This study explored differences in neural functional connectivity between participants with and without histories of childhood adversity, controlling for tendency to ruminate, during resting-state and induction of rumination. Method: A total of 86 adults (51 women) took part. Based on a diagnostic clinical interview, participants were divided into groups with and without adverse childhood experiences. All participants underwent resting-state imaging and a functional magnetic resonance imaging scan where they performed a rumination induction task. Results: Individuals with childhood adversities differed from those without adverse experiences in seed-based functional connectivity from right angular gyrus and left superior frontal gyrus during the rumination task. There were also group differences during resting-state in seedbased functional connectivity from the right angular gyrus, left middle temporal gyrus, and left superior frontal gyrus. Conclusions: Childhood adversity is associated with altered brain functioning during rumination and resting-state, even after controlling for tendency to ruminate. Our results shed light on the consequences of early adversity. People who experienced childhood adversities differ from those with no adverse experiences in brain functional connectivity when engaged in negative repetitive self-referential thinking.
关键词：Trauma;stress;rumination;functional connectivity