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标题：Effects of diclofenac on the gametes and embryonic development of Arbacia lixula
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作者：M. Mauro ; G. Cammilleri ; M. Celi 等
期刊名称：The European Zoological Journal
电子版ISSN：2475-0263
出版年度：2022
卷号：89
期号：1
页码：535-545
DOI：10.1080/24750263.2022.2059582
语种：English
出版社：Taylor & Francis Group
摘要：Diclofenac (DCF), a non-steroidal anti-inflammatory drug (NSAID), is among the main pollutants of aquatic environments. Nevertheless, even if several authors evaluated its effects on marine organisms, no work has ever analysed its impact on the sea urchin Arbacia lixula. The purpose of this study was to analyse, for the first time, the impact of DCF at different concentrations (50 mg/l, 5 mg/l, 0.5 mg/l, 0.05 mg/l) on A. lixula embryos and gametes to indicate possible safe minimum levels of release of this drug in marine environments. Our results showed significant concentration-dependent effects on embryonic development (decrease in the number of developed embryos and increase in the quantity of degenerated eggs) and significant levels of bioaccumulation at DCF concentrations of 50 mg/l in both gametes and embryos. DCF showed a significant impact on the fertilisation of A. lixula due to its effects on gametes, confirming the possibility of environmental risk and highlighting the need to improve wastewater treatment and drug disposal processes.
关键词：Anti-inflammatory;developed embryos;drugs;marine pollution;sea urchin