文章基本信息

标题：Protective efficacy of an RBD-based Middle East respiratory syndrome coronavirus (MERS-CoV) particle vaccine in llamas
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作者：Jordi Rodon ; Anna Z. Mykytyn ; Guillermo Cantero 等
期刊名称：One Health Outlook
印刷版ISSN：2524-4655
出版年度：2022
卷号：4
DOI：10.1186/s42522-022-00068-9
语种：English
摘要：Ongoing outbreaks of Middle East respiratory syndrome coronavirus (MERS-CoV) continue posing a global health threat. Vaccination of livestock reservoir species is a recommended strategy to prevent spread of MERS-CoV among animals and potential spillover to humans. Using a direct-contact llama challenge model that mimics naturally occurring viral transmission, we tested the efficacy of a multimeric receptor binding domain (RBD) particle-display based vaccine candidate. While MERS-CoV was transmitted to naïve animals exposed to virus-inoculated llamas, immunization induced robust virus-neutralizing antibody responses and prevented transmission in 1/3 vaccinated, in-contact animals. Our exploratory study supports further improvement of the RBD-based vaccine to prevent zoonotic spillover of MERS-CoV. Supplementary Information The online version contains supplementary material available at 10.1186/s42522-022-00068-9.
关键词：KeywordsenAnimal modelLlamaCamelidMiddle East respiratory syndrome coronavirusMERS-CoVMultimeric protein scaffold particles (MPSP)Receptor binding domain (RBD)-based vaccineVirus transmissionNeutralizing antibodies