文章基本信息

标题：Dopaminergic D4 receptor polymorphism among 24 populations of India: an anthropological insight
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作者：KALLUR NAVA SARASWATHY ; SANJENBAM YAIPHABA MEITEI ; HUIDROM SURAJ SINGH 等
期刊名称：Anthropological Science
印刷版ISSN：0918-7960
电子版ISSN：1348-8570
出版年度：2013
卷号：121
期号：2
页码：131-136
DOI：10.1537/ase.130609
语种：English
出版社：The Anthropological Society of Nippon
摘要：Various studies have tried to elucidate the genomics underlying the ethnic diversity of Indian populations. The 48-basepair variable number tandem repeat (VNTR) of the DRD4 gene, besides its clinical importance, has been a subject of interest for understanding human evolutionary history worldwide. In spite of its highly polymorphic nature it has not been much explored by anthropologists, especially in the Indian context. In the present study, an attempt was made to infer the allelic variation of the repeat allele among 24 Indian ethnic groups belonging to different ethnic and linguistic groups along with different geographic affiliations. Only the 2R, 3R, 4R, 5R, 6R, and 7R repeat alleles were found in the studied populations, with 4R being the most frequent followed by 2R. All the other repeat alleles (3R, 5R, 6R, and 7R) occurred at very low frequency. Based on the 4R and 5R frequencies, the study reveals a common genetic substratum of the Indian population as already proposed by earlier studies. Further, the study also highlights the inflow of genes from the north.
关键词：DRD4 gene;linguistics;tribe;caste;common genetic substratum