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标题：Beneficial commensal bacteria promote Drosophila growth by downregulating the expression of peptidoglycan recognition proteins
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作者：Marialaura Gallo ; Justin M. Vento ; Pauline Joncour 等
期刊名称：iScience
印刷版ISSN：2589-0042
出版年度：2022
卷号：25
期号：6
页码：1-20
DOI：10.1016/j.isci.2022.104357
语种：English
出版社：Elsevier
摘要：SummaryCommensal bacteria are known to promote host growth. Such effect partly relies on the capacity of microbes to regulate the host’s transcriptional response. However, these evidences mainly come from comparing the transcriptional response caused by commensal bacteria with that of axenic animals, making it difficult to identify the animal genes that are specifically regulated by beneficial microbes. Here, we employDrosophila melanogasterassociated withLactiplantibacillus plantarumto understand the host genetic pathways regulated by beneficial bacteria and leading to improved host growth. We show that microbial benefit to the host relies on the downregulation of peptidoglycan-recognition proteins. Specifically, we report that bacterial proliferation triggers the lower expression of PGRP-SC1 in larval midgut, which ultimately leads to improved host growth and development. Our study helps elucidate the mechanisms underlying the beneficial effect exerted by commensal bacteria, defining the role of immune effectors in the relationship between Drosophila and its gut microbes.Graphical abstractDisplay OmittedHighlights•BeneficialL. plantarumstrains downregulate the expression ofDrosophilaPGRP-SC1•L. plantarumproliferation triggers the lower expression ofDrosophilaPGRP-SC1•Downregulation of PGRP-SC1 relies on the loss of function ofL. plantarum ackAgene•PGRP-SCs downregulation is sufficient to improveL. plantarumbeneficial effectImmunology; Microbiology; Microbiome