文章基本信息

标题：Altered synaptic plasticity of the longitudinal dentate gyrus network in noise-induced anxiety
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作者：Sojeong Pak ; Gona Choi ; Jaydeep Roy 等
期刊名称：iScience
印刷版ISSN：2589-0042
出版年度：2022
卷号：25
期号：6
页码：1-20
DOI：10.1016/j.isci.2022.104364
语种：English
出版社：Elsevier
摘要：SummaryAnxiety is characteristic comorbidity of noise-induced hearing loss (NIHL), which causes physiological changes within the dentate gyrus (DG), a subfield of the hippocampus that modulates anxiety. However, which DG circuit underlies hearing loss-induced anxiety remains unknown. We utilize an NIHL mouse model to investigate short- and long-term synaptic plasticity in DG networks. The recently discovered longitudinal DG-DG network is a collateral of DG neurons synaptically connected with neighboring DG neurons and displays robust synaptic efficacy and plasticity. Furthermore, animals with NIHL demonstrate increased anxiety-like behaviors similar to a response to chronic restraint stress. These behaviors are concurrent with enhanced synaptic responsiveness and suppressed short- and long-term synaptic plasticity in the longitudinal DG-DG network but not in the transverse DG-CA3 connection. These findings suggest that DG-related anxiety is typified by synaptic alteration in the longitudinal DG-DG network.Graphical abstractDisplay OmittedHighlights•Traumatic noise-induced hearing loss enhances anxiety-like behaviors•The longitudinal DG-DG network displays robust synaptic efficacy and plasticity•Abnormal anxiety is associated with synaptic alterations of the DG-DG network•DG-related brain disorders might stem from dysfunctional DG-DG networksBiological sciences; Neuroscience; Behavioral neuroscience