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标题：COH04S1 and beta sequence-modified vaccine protect hamsters from SARS-CoV-2 variants
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作者：Felix Wussow ; Mindy Kha ; Katelyn Faircloth 等
期刊名称：iScience
印刷版ISSN：2589-0042
出版年度：2022
卷号：25
期号：6
页码：1-16
DOI：10.1016/j.isci.2022.104457
语种：English
出版社：Elsevier
摘要：SummaryCOVID-19 vaccine efficacy is threatened by emerging SARS-CoV-2 variants of concern (VOC) with the capacity to evade protective neutralizing antibody responses. We recently developed clinical vaccine candidate COH04S1, a synthetic modified vaccinia Ankara vector (sMVA) co-expressing spike and nucleocapsid antigens based on the Wuhan-Hu-1 reference strain that showed potent efficacy to protect against ancestral SARS-CoV-2 in Syrian hamsters and non-human primates and was safe and immunogenic in healthy volunteers. Here, we demonstrate that intramuscular immunization of Syrian hamsters with COH04S1 and an analogous Beta variant-adapted vaccine candidate (COH04S351) elicits potent cross-reactive antibody responses and protects against weight loss, lower respiratory tract infection, and lung pathology following challenge with major SARS-CoV-2 VOC, including Beta and the highly contagious Delta variant. These results demonstrate efficacy of COH04S1 and a variant-adapted vaccine analog to confer cross-protective immunity against SARS-CoV-2 and its emerging VOC, supporting clinical investigation of these sMVA-based COVID-19 vaccine candidates.Graphical abstractDisplay OmittedHighlights•sMVA-vectored COVID-19 vaccines based on SARS-CoV-2 ancestral virus or Beta variant•Vaccinated hamsters develop antibodies to ancestral virus and variants of concern•Vaccines protect hamsters against ancestral SARS-CoV-2 and Beta and Delta variants•sMVA vectors induce potent cross-protective immunity to SARS-CoV-2 and its variantsBiological sciences; Immunology; Virology