文章基本信息

标题：Association between SORT1 gene polymorphism studies in obesity population
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作者：Mohamed Farouk Elsadek ; Alia Almoajel
期刊名称：Journal of King Saud University - Science
印刷版ISSN：1018-3647
出版年度：2022
卷号：34
期号：5
页码：1-4
DOI：10.1016/j.jksus.2022.102052
语种：English
出版社：Elsevier
摘要：Obesity is defined the accumulation of extra fat deposited in the body. Based on body mass index (BMI), obesity is classified in children and adults of both men and women. Sortilin 1 (SORT1) gene has been documented with the relationship of low-density lipoprotein cholesterol (LDLC) and coronary artery disease. However, the relation between obesity and LDLC is well documented. The aim of this study was to investigate the relation between rs464218 SNP genotype assay inSORT1gene among obesity subjects in the Saudi population. One hundred forty samples were categorized as 80 obesity and 60 control subjects. DNA was extracted to perform PCR for rs464218 SNP genotype assay using restriction enzyme. Based on clinical and genotype data, statistical analysis will be performed. The clinical data documents weight, Body Mass Index, High Density Lipoprotein Cholesterol, LDLC and Triglycerides were associated in obese group (p < 0.05). Hardy-Weinberg Equilibrium analysis revealed the deviation with rs464218 SNP genotype assay. None of the genotypes, dominant model and allelic frequencies showed the significant association among obese groups (p > 0.05). Anova analysis revealed the positive association among weight, BMI and LDLC among obese groups (p < 0.05). In conclusion, the rs464218 SNP genotype assay ofSORT1gene doesn’t showed the genotype association but Anova analysis revealed the positive connection between obesity and LDLC. Future studies are required with large number of sample size.
关键词：ObesitySORT1LDLCCAD and SNP genotype assay