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标题：Development of saline loaded mask materials, evaluation of the antimicrobial efficacy and survivability of selected bacteria on these mask materials
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作者：Julnar Evangelista Pepito ; Jayachandran Vavolil Prabhakaran ; Dinesh Kada Peela Bheeman 等
期刊名称：Journal of King Saud University - Science
印刷版ISSN：1018-3647
出版年度：2022
卷号：34
期号：5
页码：1-11
DOI：10.1016/j.jksus.2022.102125
语种：English
出版社：Elsevier
摘要：AbstractObjectiveSurgical face masks have been recommended by World Health Organization (WHO) during the COVID-19 pandemic. Nowadays wearing masks have become a norm and lifestyle around the globe. The present investigation was carried out to evaluate the feasibility of developing masks loaded with analytical grade sodium chloride (NaCl), Iodized salts (IS) and Omani sea salt (OSS) with or without sodium bicarbonate (NaHCO3).MethodsThe saline loaded masks were prepared by soaking the middle layer of the mask in 30% (w/v) saline solutions (NaCl, IS, OSS) with or without 10% NaHCO3for 24 h followed by drying at room temperature. The prepared saline solutions and its combinations were evaluated for antimicrobial efficacy against the bacteria likeEscherichiacoli,Pseudomonas aeruginosa,Proteus vulgaris,Salmonella typhi, and Staphylococcus aureus, and antifungal activity against thePenicilliumspp. and Rhizopus spp. by agar diffusion. Optical microscopy was employed to observe the formation of salt crystal in the mask material. Survivability ofS. aureusandP. aeruginosawas tested on the mask material loaded with 30% OSS + 10% NaHCO3at particular time intervals.ResultsThe results showed that a combination of 30% OSS + 10% NaHCO3exhibited promising antimicrobial activity against all the bacteria as well as Rhizopus spp. compared to the 30% IS + 10% NaHCO3. Moreover, the middle layer of the mask loaded with saline solutions of 30% OSS + 10% NaHCO3or 30% IS + 10% NaHCO3have antibacterial activity, particularly for oral microbiome. On dehydration, the masks materials showed the presence of a significant amount of salt crystals. Survivability tests showed that bothS. aureusandP. aeruginosawere killed within 3 h of contact with the salt crystals on the mask materials.ConclusionsA combination of 30% OSS + 10% NaHCO3possessed significant antimicrobial activities on the tested microorganisms. Presence of a significant amount of salt crystals on dehydration of the saline loaded masks can be used as an effective protective barrier to infectious respiratory agents.
关键词：KeywordsSurgical maskOmani sea saltSodium bicarbonateAntimicrobial activitySalt crystals