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标题：Effects of Different Solvents to Extract Phytochemical Materials of Rhazya stricta Against Salmonella typhimurium Activity
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作者：Bahman Fazeli-Nasab ; Hassan Ahmadi ; Mehrangiz Ghafari 等
期刊名称：Gene, Cell and Tissue
印刷版ISSN：2345-6841
出版年度：2022
卷号：9
期号：1
DOI：10.5812/gct.117543
语种：English
出版社：Zahedan University of Medical Sciences
摘要：The use of plant extracts prepared from medicinal plants is common in the developing countries. Meanwhile, due to the resistance of microorganisms to antibiotics, researchers are looking to discover new antimicrobials. Medicinal plants play an essential role in this regard. Objectives: This study was aimed at investigating the antimicrobial properties of various extracts of Rhazya stricta plant against Salmonella typhimurium. Methods: Methanolic, aqueous, ethanolic, hydroalcoholic, and ethyl acetate extracts of R. stricta were prepared. Salmonella typhimurium strains were isolated from poultry feces. The microdilution method was used to determine the minimum inhibitory concentration (MIC) and the minimum bactericidal concentration (MBC) of this plant. The diameter of the growth inhibition zone using was determined using Whatman paper. Results: The lowest MIC against S. typhimurium was obtained from the hydroalcoholic solvent with 3.1 ppm. The most effective extraction solvent to inhibit the growth of S. typhimurium was the hydroalcoholic type with an average growth inhibition zone diameter of 12.25 mm, followed by the ethanolic extract with a growth inhibition zone diameter of 12.12 mm. Conclusions: According to the results of research and increasing resistance to synthetic antibacterial substances, it seems that R. stricta plant with the help of hydroalcoholic solvent, can be considered an effective plant in eliminating some bacteria, including S. typhimurium.
关键词：Ethanolic;Methanolic;Antibacterial;Hydroalcoholic;Ethyl Acetate