摘要:Nowadays, arthritis and cardiovascular disease are common disorders among people. Arthritis is a condition which causes pain, stiffness, and swelling in joint (1). In osteoarthritis which is the most common type of arthritis, the protective cartilage among bones begins to weaken, and the bones will be worn out, causing pain in person (2). The cardiovascular disease affecting the heart or blood vessels which is usually related to a build-up of fatty deposits inside the vessels (atherosclerosis). There are many factors involved in developing osteoarthritis and atherosclerosis, some of which, such as age and genetics, are not under human control (3, 4). Some factors such as muscle weakness, inactivity, and overweight are factors which can be controlled during the life (5-8). However, studies show that subjects who suffer from these conditions for any reason can recover with proper aerobic training and ozone therapy (5, 9-11). Due to the reports, aerobic training and ozone therapy positively affect genes related to cardiovascular health in the heart tissue of rats with osteoarthritis (9). Furthermore, combined therapies with aerobic training and ozone improve some biochemical variables in cartilage tissue of rats with knee osteoarthritis (12). Aerobic training decreases the risk of ischemia-related cardiac dysfunction/death (13). Aerobic training via several mechanisms such as changes in reverse cholesterol transport elements has a positive effect on heart health and function (7, 14-17). Aerobic training (under physician supervision) can help treat osteoarthritis and reduce pain by increasing muscle and tendon function as well as weight loss (18).