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标题：Effects of Baru Almond Oil ( Dipteryx alata Vog.) Treatment on Thrombotic Processes, Platelet Aggregation, and Vascular Function in Aorta Arteries
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作者：Cristiane Cosmo Silva-Luis ; José Luiz de Brito Alves ; Júlio César Pinheiro Lúcio de Oliveira 等
期刊名称：Nutrients
电子版ISSN：2072-6643
出版年度：2022
卷号：14
期号：10
DOI：10.3390/nu14102098
语种：English
出版社：MDPI Publishing
摘要：Background: This study assessed the effects of Baru ( Dipteryx alata Vog.) almond oil supplementation on vascular function, platelet aggregation, and thrombus formation in aorta arteries of Wistar rats. Methods: Male Wistar rats were allocated into three groups. The control group ( n = 6), a Baru group receiving Baru almond oil at 7.2 mL/kg/day (BG 7.2 mL/kg, n = 6), and (iii) a Baru group receiving Baru almond oil at 14.4 mL/kg/day (BG 14.4 mL/kg, n = 6). Baru oil was administered for ten days. Platelet aggregation, thrombus formation, vascular function, and reactive oxygen species production were evaluated at the end of treatment. Results: Baru oil supplementation reduced platelet aggregation ( p < 0.05) and the production of the superoxide anion radical in platelets ( p < 0.05). Additionally, Baru oil supplementation exerted an antithrombotic effect ( p < 0.05) and improved the vascular function of aorta arteries ( p < 0.05). Conclusion: The findings showed that Baru oil reduced platelet aggregation, reactive oxygen species production, and improved vascular function, suggesting it to be a functional oil with great potential to act as a novel product for preventing and treating cardiovascular disease.
关键词：enDipteryx alata Vog.Fabaceaetocopherolsthrombosisplatelet aggregationvascular response